Cryo-EM epitope mapping: SARS-CoV-2 spike protein antibodies

Cryo-EM epitope mapping: SARS-CoV-2 spike protein antibodies

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Learn from recent drug discovery case studies that leverage cutting-edge cryo-EM workflow advancements and technologies

https://journals.asm.org/cms/10.1128/Spectrum.01416-21/asset/8f0f2598-78d3-4f3a-a57e-0aafe0cb9839/assets/images/large/spectrum.01416-21-f001.jpg

Mapping SARS-CoV-2 Antibody Epitopes in COVID-19 Patients with a Multi-Coronavirus Protein Microarray

https://onlinelibrary.wiley.com/cms/asset/390375f0-b2a2-4c72-823c-e3f9cc4decde/rmv2347-fig-0001-m.jpg

Epitope mapping of neutralising anti‐SARS‐CoV‐2 monoclonal antibodies: Implications for immunotherapy and vaccine design - Ghotloo - 2022 - Reviews in Medical Virology - Wiley Online Library

https://www.mdpi.com/vaccines/vaccines-09-01419/article_deploy/html/images/vaccines-09-01419-g001.png

Vaccines, Free Full-Text

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State of the art in epitope mapping and opportunities in COVID-19

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Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology - ScienceDirect

https://pub.mdpi-res.com/ijms/ijms-23-02928/article_deploy/html/images/ijms-23-02928-g001.png?1646756334

IJMS, Free Full-Text

https://iiif.elifesciences.org/lax:83710%2Felife-83710-fig3-v3.tif/full/1500,/0/default.jpg

Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses

https://www.frontiersin.org/files/Articles/1192385/fimmu-14-1192385-HTML/image_m/fimmu-14-1192385-g001.jpg

Frontiers Massively-multiplexed epitope mapping techniques for viral antigen discovery

https://pubs.rsc.org/image/article/2021/CB/d1cb00169h/d1cb00169h-f2_hi-res.gif

An overview of methods for the structural and functional mapping of epitopes recognized by anti-SARS-CoV-2 antibodies - RSC Chemical Biology (RSC Publishing) DOI:10.1039/D1CB00169H

https://www.mdpi.com/viruses/viruses-15-00558/article_deploy/html/images/viruses-15-00558-g001.png

Viruses, Free Full-Text

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Identification of COVID-19 B-cell epitopes with phage-displayed peptide library, Journal of Biomedical Science

https://www.science.org/cms/10.1126/science.abn8897/asset/22b5268c-4e1e-4645-8e8b-2d8f35bb5063/assets/images/large/science.abn8897-f1.jpg

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529