Accurate design of megadalton-scale two-component icosahedral protein  complexes – Baker Lab

Accurate design of megadalton-scale two-component icosahedral protein complexes – Baker Lab

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https://www.pnas.org/cms/10.1073/pnas.2221745120/asset/82571977-49b9-40da-a506-5a1a34abadc5/assets/images/large/pnas.2221745120fig02.jpg

More than just pattern recognition: Prediction of uncommon protein structure features by AI methods

https://cdn.rcsb.org/images/structures/6eqe_model-1.jpeg

RCSB PDB - 6EQE: High resolution crystal structure of a polyethylene terephthalate degrading hydrolase from Ideonella sakaiensis

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Accurate design of megadalton-scale two-component icosahedral protein complexes

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Genome-wide tiled detection of circulating Mycobacterium tuberculosis cell-free DNA using Cas13

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Accurate design of megadalton-scale two-component icosahedral protein complexes

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De novo design of obligate ABC-type heterotrimeric proteins

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Accurate design of large icosahedral protein

https://www.science.org/cms/10.1126/science.aaq1739/asset/6c94412f-1311-4b37-8556-92c9ee01493a/assets/graphic/359_1042_f4.jpeg

Accurate computational design of multipass transmembrane proteins

https://cdn.rcsb.org/images/structures/7o1q_model-1.jpeg

RCSB PDB - 7O1Q: Amyloid beta oligomer displayed on the alpha hemolysin scaffold

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Accurate design of megadalton-scale two-component icosahedral protein complexes – Baker Lab

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Accurate design of megadalton-scale two-component icosahedral protein complexes

https://cdn.rcsb.org/images/structures/3blg_chain-A.jpeg

RCSB PDB - 3BLG: STRUCTURAL BASIS OF THE TANFORD TRANSITION OF BOVINE BETA-LACTOGLOBULIN FROM CRYSTAL STRUCTURES AT THREE PH VALUES; PH 6.2

https://www.ipd.uw.edu/wp-content/uploads/2016/06/icos_full.png

Icosahedral protein nanocage – new paper and podcast - Institute for Protein Design

https://cdn.rcsb.org/images/structures/6e9f_model-1.jpeg

RCSB PDB - 6E9F: EsCas13d-crRNA-target RNA ternary complex

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Design of multi-scale protein complexes by hierarchical building block fusion